Colchicum affects markedly muscles, fibrous tissue, serous membranes, joints, especially the small ones. Stitching, jerking, drawing pains in muscles, periosteum and joints. Uric acid diathesis, the sediment being pale yellow and rather like fine flour than sand. Also, urine black as ink, urine loaded with albumen and casts. The stomach is acutely disordered, nausea and vomiting. Nausea at thought, sight or smell of food, especially of cooking is a characteristic symptom. There is great prostration, internal coldness and a tendency to collapse.